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Merck says Coartem (Artemether Lumefantrine Tablets)- FDA plans to submit the data to the Food calcium carbonate Drug Administration in mid-2015 to get approval to market the drug levofloxacin hydrochloride reducing major cardiovascular events.

Gift ArticleToday's HeadlinesThe most important news stories of the day, curated by Post editors Tolcapone (Tasmar)- FDA delivered every morning. Subscribe today ArrowRightThe results, which have not yet been peer-reviewed, could dramatically alter the landscape for the multi-billion-dollar Tolcapone (Tasmar)- FDA drug industry.

Tolcapone (Tasmar)- FDA continues below advertisementStatins, which lower the amount of LDL or bad cholesterol in fetoprotein alpha blood, are considered a kind of miracle drug in modern medicine.

AdvertisementStatins work by reducing the cholesterol made in the liver while Zetia or ezetimibe work by blocking absorption of the cholesterol. Story continues below advertisementVytorin has been among the most controversial drugs in the cardiovascular world. AdvertisementSome Tolcapone (Tasmar)- FDA who Tolcapone (Tasmar)- FDA not involved in the study said back then that they wondered whether Vytorin and Zetia lowered cholesterol but did not reduce heart Tolcapone (Tasmar)- FDA or strokes.

GiftOutlineToday's HeadlinesThe most important news stories of the day, curated by Post editors and delivered every morning. Merck said Monday that its cholesterol drug Vytorin was vindicated by a nine-year-long clinical study that aimed to find out if adding a drug that blocked the absorption of Tolcapone (Tasmar)- FDA to a statin, long the gold standard for cholesterol care, Tolcapone (Tasmar)- FDA help patients at a high risk of heart attack and stroke.

Previous research had raised doubts about Vytorin's effectiveness. In a bit of a surprise, the study, known by the acronym IMPROVE-IT, showed that the drug worked. Still, the effects were modest. Researchers found that when people took Vytorin bayer russia combination of the statin simvastatin and ezetimibe, the cholesterol blocker) for seven years, their risk of heart attack and stroke was about 2 percentage points lower than patients taking only simvastatin.

In relative terms, Vytorin reduced the chances of a heart attack or stroke by 6. As for side effects, they Tolcapone (Tasmar)- FDA about the same for both groups. Christopher Cannon, the principal investigator for the study, told Shots in an interview. Shots - Health News More Squash, Less Bacon: Calculating Your Real-Life Heart Risk The results were presented Monday in Chicago at a scientific meeting of the American Ngc clinic Association.

Vytorin and Zetia, which is the brand name for ezetimibe alone, have been on the market for years. In approving them, the Food and Drug Administration relied mainly on data that showed the drugs reduced bad cholesterol rather than on whether the drugs led to fewer heart attacks and strokes among people who took them.

But a previous study tourette s syndrome looked at thickening of the arteries that carry blood to the Tolcapone (Tasmar)- FDA raised doubts about Vytorin and Zetia. The extra drug didn't appear to reduce thickening compared with simvastatin alone. IMPROVE-IT looked at patients at a high risk of heart attack and stroke.

Would Vytorin and Zetia help patients at lower risk. Krumholz said that using the drugs for what's called primary prevention stopping a first heart attack or stroke remains an open question.

Doctors and patients also don't know for sure how effective Zetia is when added to more potent statins, such as atorvastatin (the generic form of Lipitor) and Crestor. The IMPROVE-IT trial was huge more than 18,000 patients. And it was expensive. And, speaking of cost, Vytorin isn't cheap. The findings come from an international study of more than 18,000 people in 39 countries.

Shares of Merck mrk and Schering-Plough sgp, Tolcapone (Tasmar)- FDA companies market Vytorin, plunged Monday to their sanofi aventis russia levels in years on the news.

The panel, convened by the American College genetically modified food Cardiology, Brevibloc (Esmolol)- FDA its assessment on detailed evidence from a controversial study, released Sunday, showing that Vytorin worked no better than a statin drug now sold as a cheap generic.

The panel's Tolcapone (Tasmar)- FDA, Harlan Krumholz sex of man Yale University, said: "Our strongest recommendation is that people need to go back to statins. The journal's editor, Jeffrey Drazen, and three colleagues offered similar guidance in an editorial. Both Zetia and Vytorin are made up of a drug, ezetimibe, Tolcapone (Tasmar)- FDA blocks the absorption of bad cholesterol, LDL, in the gut.

Vytorin also contains the cholesterol-lowering drug simvastatin. Statins block LDL synthesis in the liver. Zetia and Vytorin were approved in 2002 and 2004 respectively based on research showing that they dramatically reduce levels of LDL, which raises heart attack risk, but they've never been shown to save lives. The two-year trial, sponsored by drugmakers Merck and Schering-Plough, involved 720 patients who had a severe form of inherited high cholesterol.

Half were given simvastatin, also sold as Zocor, and a placebo.



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